Refereed Journal Articles


Eijkelkamp, B.A., Morey, J.R., Neville, S.L., Tan, A., Pederick, V.G., Cole, N., Singh, P.P., Ong, C-Y., Gonzalez de Vega, R., Clases D., Cunningham, B.A., Hughes, C.E., Comerford, I., Brazel, E.B., Whittall, J.J., Plumptre, C.D., McColl, S.R., Paton, J.C., McEwan, A.G., Doble, P.A. and McDevitt, C.A. (2019) Dietary zinc and the control of Streptococcus pneumoniae PLoS Pathogens. 5:e1007957

Monk, I.R., Shaikh, N., Begg, S.L., Gajdiss, M., Sharkey, L.K.R., Lee, J.H.Y., Pidot, S.J., Seemann, T., Kuiper, M., Winnen, B., Hvorup, R., Collins, B.M., Bierbaum, G., Udagedara, S.R., Morey, J.R., Pulyani, N., Howden, B.P., Maher, M.J., McDevitt, C.A., King, G.F., and Stinear, T.P. (2019) Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus. Nature Communications DOI: 10.1038/s41467-019-10932-4

Luo, Z., Neville, S.L., Campbell, R., Morey, J.R., Menon, S., Thomas, M., Ween, M.P., Eijkelkamp, B.A., Huston, W., Kobe, B. and McDevitt, C.A. (2019) Crystal structure and metal binding properties of Chlamydia trachomatis J. Bacteriol. DOI: 10.1128/JB.00580-19

Alquethamy, S., Adams, F.G., Naidu, V., Khorvash, M., Pederick, V.G., Zang, M., Paton, J.C., Paulsen, I.T., Hassan, K., Cain, A.K., McDevitt, C.A. and Eijkelkamp, B.A. (2019) The role of zinc efflux during Acinetobacter baumannii ACS Infect. Dis. DOI: 10.1021/acsinfecdis.9b00351

de Boer, M., Gouridis, G., Vietrov, R., Begg, S.L., Schuurman-Wolters G.K., Husada, F., Eleftheriadis, N., Poolman, B., McDevitt, C.A. and Cordes, T. (2019) Conformational and dynamical plasticity in substrate-binding proteins underlies selective transport in ABC importers. eLife  DOI: 10.7554/eLife.44652

Moulin, P., Rong, V., Ribeiro E Silva, A., Pederick, V.G., Camiade, E., Mereghetti, L., McDevitt, C.A. and Hiron, A. (2019) Defining the role of the Streptococcus agalactiae Sht proteins in zinc acquisition and complement evasion. Bacteriol. DOI: 10.1128/JB.00757-18

Alquethamy, S.F., Khorvash, M., Pederick, V.G., Whittall, J.J., Paton, J.C., Paulsen, I.T., Hassan, K.A., McDevitt, C.A. and Eijkelkamp, B.A. (2019) The role of the CopA copper efflux system in Acinetobacter baumannii Int. J. Mol. Sci. 20:575

Jiang, J-H., Hassan, K.A., Begg, S.L., Rupasinghe, T.W.T., Naidu, V., Pederick, V.G., Khorvash, M., Whittall, J.J., Paton, J.C., Paulsen, I.T., McDevitt, C.A., Peleg, A.Y. and Eijkelkamp, B.A. (2019) Identification of novel Acinetobacter baumannii host fatty acid stress adaptation strategies. mBio 10:1 e02056-18

Sikanyika, M., Aragão, D., McDevitt, C.A. and Maher M.J. (2019) The structure and activity of the glutathione reductase from Streptococcus pneumoniae. Acta Crystallographica Section F F75:54-61

Bohlmann, L., De Oliveira, D.M.P., El-Deeb, I.M., Brazel, E.B., Harbison-Price, N., Ong, C.Y., Rivera Hernandez, T., Ferguson, S.A., Walker, A.J., Phan, M.D., Davies, M.R., Nimmo, G.R., Dougan, G., Schembri, M.A., Cook, G., McEwan, A.G., von Itzstein, M., McDevitt, C.A. and Walker, M.J. (2018) Chemical synergy between ionophore PBT2 and zinc reverses antibiotic resistance. mBio 9:e02391-18

Radin, J.N., Zhu, J., Brazel, E.B., McDevitt, C.A. and Kehl-Fie, T.E. (2019) Synergy between nutritional immunity and independent host defenses contributes to the importance of the MntABC manganese transporter during Staphylococcus aureus


Zhang, X., Heng, S., Pei, J., Morey, J.R., McDevitt, C.A. and Abell, A. (2018) A liposomal platform for exclusive sensing of extracellular analytes near cells. Biosensors 8:117

Karami, A., Zhang, H. Pederick, V.G., McDevitt, C.A., Kabir, M.S., Xu, S., Munroe, P., Zhou, Z., and Xie, A. (2018) Cr-Ag coatings: synthesis, microstructure and antimicrobial properties. Surface Engineering 1-8

Young, R.J., Begg, S.L. Coghlan, C.J., McDevitt, C.A. and Sumby C.J. (2018) Exploring the use of structure and polymer incorporation to tune silver ion release and antibacterial activity of silver coordination polymers. (2018) European Journal of Inorganic Chemistry 30:3512-3518

Luo, Z., Pederick, V.G., Paton, J.C., McDevitt, C.A. and Kobe, B. (2018) Structural characterisation of the HT3 motif of the polyhistidine triad protein D from Streptococcus pneumoniae. FEB Lett 592:2341-2350

Eijkelkamp, B.A., Begg, S.L., Pederick, V.G., Trapetti, C., Gregory, M.K., Whittall, J.J., Paton, J.C. and McDevitt, C.A. (2018) Arachidonic acid stress impacts pneumococcal fatty acid homeostasis. Frontiers in Microbiology 9:813

Kidsley, A.K., Abraham, S., Bell, J., O’Dea, M., Laird, T.J., Jordan, D., Mitchell, P., McDevitt, C.A. and Trott, D.J. (2018) Antimicrobial susceptibility of Escherichia coli and Salmonella isolates from healthy pigs in Australia: results of a pilot national survey. Frontiers in Microbiology 9:1207

Satiaputra, J., Eijkelkamp, B.A., McDevitt, C.A., Shearwin, K.E., Booker, G.W. and Polyak, S.W. (2018) Biotin-mediated growth and gene expression in Staphylococcus aureus is highly responsive to environmental biotin availability. Applied Microbiology and Biotechnology 102:3793-03

Ryan, T.M., Trewhella, J., Murphy, J.M., Keown, J.R., Casey, L., Pearce, F.G., Goldstone, D.C., Chen, K., Luo, Z., Kobe, B., McDevitt C.A., Watkin, S.A., Hawley, A.M., Mudie, S.T., Samardzic Boban V. and Kirby, N. (2018) An optimized SEC-SAXS system enabling high X-ray dose for rapid SAXS assessment with correlated UV measurements for biomolecular structure analysis. Journal of Applied Crystallography. 50:1-15


Grim, K., San Francisco, B. Radin, J., Brazel, E.B., Kelliher, J., Párraga Solórzano, P. Kim, P., McDevitt, C.A. and Kehl-Fie, T. (2017) The metallophore staphylopine enables Staphylococcus aureus to compete with the host for zinc and overcome nutritional immunity. 8:e01281-17

Eyre, N.S., Johnson, S.M., Eltahla, A.A., Aloi, M., Aloia, A.L., McDevitt, C.A., Bull, R.A. and Beard, M.R. (2017) Genome-wide mutagenesis of dengue virus reveals plasticity of the NS1 protein and enables generation of infectious tagged reporter viruses. Journal of Virology. 91:e01455-17

Martin, J.M., Edmonds, K.A., Bruce, K.E., Campanello, G.C., Eijkelkamp, B.A., Brazel, E.B., McDevitt, C.A., Winkler, M.E., and Giedroc, D.P. (2017) The zinc efflux activator SczA protects Streptococcus pneumoniae 1 serotype 2 D39 from intracellular zinc toxicity Molecular Microbiology

Hassan, K.A., Pederick, V.G., Elbourne, L.D.H., Paulsen, I.T., Paton, J.C., McDevitt, C.A.# and Eijkelkamp B.A.# (2017) Zinc stress induces copper depletion in Acinetobacter baumannii. BMC Microbiology. (#co-corresponding authors)

Trappetti, C., McAllister, L.J., Chen, A., Wang, H., Paton, A.W., Oggioni, M.R., McDevitt, C.A., and Paton, J.C. (2017) Autoinducer 2 signaling via the phosphotransferase FruA drives galactose utilization by Streptococcus pneumoniae, resulting in hypervirulence. mBio. 8: e02269-16


Heng, S., McDevitt, C.A., Kostecki, R., Morey, J.R., Eijkelkamp, B.A., Monro, T., Abell, A.D. (2016) Microstructured optical fiber-based biosensors: Reversible and nanoliter-scale measurement of zinc ions. ACS Applied Materials and Interfaces. 8:12727-32


Luo, Z., Morey, J.R., McDevitt, C.A., Kobe B. Heterogeneous nucleation is required for crystallization of the ZnuA domain of pneumococcal AdcA. (2015) Acta Crystallogr. F Struct. Biol. Commun. 71:1459-1464

Eijkelkamp, B.A., Pederick, V.G., Plumptre, C.D., Harvey, R.M., Hughes, C.E., Paton, J.C., McDevitt, C.A. The first histidine triad motif of PhtD is critical for zinc homeostasis in Streptococcus pneumoniae. (2015) Infection and Immunity. doi: 10.1128/IAI.01082-15

Deplazes, E.*, Begg, S.L.*, van Wonderen, J.H., Cambpell, R., Kobe, B. Paton, J.C., MacMillan F., McDevitt, C.A.# and O'Mara M.L.# (2015) Characterising the conformational dynamics of metal-free PsaA using molecular dynamics simulations and electron paramagnetic resonance spectroscopy. Biophysical Chemistry. 207:51-60 [pdf] [*equal first author; #co-corresponding authors]

Pederick, V.G., Eijkelkamp, B.A., Begg, S.L., Ween, M.P., McAllister, L.J., Paton, J.C., and McDevitt, C.A. (2015) ZnuA and zinc homeostasis in Pseudomonas aeruginosa. Scientific Reports. 5:13139 [pdf]

Begg, S.L., Eijkelkamp, B.A., Luo, Z., Couñago, R.M., Morey, J.R., Maher, M.J., Ong C.Y., McEwan, A.G., Kobe, B., O'Mara M.L., Paton, J.C., and McDevitt, C.A. (2015) Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae. Nature Communications. 6:6418 [pdf]

Bajaj, M., Mamidyala, S.K., Zuegg, J., Begg, S.L., Ween, M.P., Luo, Z., Huang, J.X., McEwan, A.G., Kobe, B., Paton, J.C., McDevitt, C.A., and Cooper M.A. (2015) Discovery of novel Pneumococcal surface antigen A (PsaA) inhibitors using a fragment-based drug design approach. ACS Chemical Biology 10:1511-20 [pdf]


Pederick, V.G., Eijkelkamp, B.A., Ween, M.P., Begg, S.L., Paton, J.C. and McDevitt, C.A. (2014) The acquisition and role of molybdate in Pseudomonas aeruginosa. Applied and Environmental Microbiology. 80:6843-6852 [pdf]

Plumptre, C.D., Hughes, C.E., Harvey, R.M., Eijkelkamp, B.A., McDevitt, C.A. and Paton, J.C. (2014) Overlapping functionality of the Pht proteins in zinc homeostasis of Streptococcus pneumoniae. Infection and Immunity. 82:4315-4324 [pdf]

van Wonderen J.H., McMahon R.M., O'Mara M.L., McDevitt C.A., Thomson A.J., Kerr I.D., MacMillan F., and Callaghan R. (2014) The central cavity of ABCB1 undergoes alternating access during ATP hydrolysis. FEBS Journal. 281:2190-201 [pdf]

Eijkelkamp, B.A., Morey, J.R., Ween, M.P., Ong, C.Y., McEwan, A.G., Paton, J.C., and McDevitt, C.A. (2014) Extracellular zinc competitively inhibits manganese uptake and compromises oxidative stress management in Streptococcus pneumoniaePLoS ONE. 9:e89427 [pdf]

Plumptre, C.D.*, Eijkelkamp, B.A.*, Morey, J.R., Behr, F., Couñago, R.M., Ogunniyi, A.D., Kobe B., O'Mara, M.L., Paton, J.C., and McDevitt, C.A. (2014) AdcA and AdcAII employ distinct zinc acquisition mechanisms and contribute additively to zinc homeostasis in Streptococcus pneumoniae. Molecular Microbiology. 91:834-51 [pdf] [*equal first author]

Couñago, R.M.*, Ween, M.P.*, Begg S.L., Bajaj, M., Zuegg, J., O'Mara, M.L., Cooper, M.A., McEwan, A.G., Paton, J.C., Kobe, B., and McDevitt, C.A. (2014) Imperfect coordination chemistry facilitates metal ion release in the Psa permease. Nature Chemical Biology. 10:35-41. [pdf] [*equal first author]
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Pollock, N.L., McDevitt, C.A., Collins, R.F., Niesten, P.H.M., Prince, S., Kerr, I.D., Ford, R.C., and Callaghan, R. (2014) Improving the stability and function of purified ABCB1 and ABCA4: The influence of membrane lipids. Biochim Biophys Acta. 1838:134-47. [pdf]


Heng S., McDevitt C.A., Stubing D.B., Whittall J.J., Thompson J.G., Engler T.K., Abell A.D. and Monro T.M. (2013) Microstructured optical fibers and live cells: a water-soluble, photochromic zinc sensor. Biomacromolecules. 14:3376-9. [pdf]


McDevitt, C.A., Ogunniyi, A.D., Valkov, E., Lawrence, M.C., Kobe, B., McEwan, A.G., and Paton, J.C. (2011) A molecular mechanism for bacterial susceptibility to zinc. PLoS Pathogens 7:e1002357 [pdf]

2010 and earlier

Ogunniyi, A.D., Mahdi, L.K., Jennings, M.P., McEwan, A.G., McDevitt C.A., Van der Hoek, M.B., Bagley, C.J., Hoffman, P., Gould, K.A., and Paton, J.C. (2010) Central role of manganese in regulation of stress responses, physiology and metabolism in Streptococcus pneumoniae. Journal of Bacteriology 192:4489-97. [pdf]

McDevitt, C.A., Collins, R.F., Kerr, I.D., and Callaghan, R. (2009) Purification and structural analyses of ABCG2. Advanced Drug Delivery Reviews 61:57-65 [pdf]

McDevitt, C.A., Crowley, E.H., Hobbs, G., Starr, K., Kerr, I.D., and Callaghan, R. (2008) Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2? FEBS Journal 275:4354-62 [pdf]

McDevitt, C.A., Shintre, C.A., Grossmann, G.J., Pollock, N.L., Prince, S.M., Callaghan, R., Ford, R.C. (2008) Structural insights into P-glycoprotein (ABCB1) by small angle X-ray scattering and electron crystallography. FEBS Letters 582:2950-6 [pdf]

McDevitt, C.A., Sargent, F., Palmer, T., and Berks, B. C. (2006) Subunit composition and in vivo substrate-binding characteristics of Escherichia coli Tat protein complexes expressed at native levels. FEBS Journal 273:5656-68 [pdf]

McDevitt, C.A., Collins R.F., Conway M., Modok S., Storm J., Kerr I.D., Ford R.C. and Callaghan R., (2006) Purification and 3-D structural analysis of oligomeric human multidrug transporter ABCG2. Structure 14:1623-32 [pdf]

Gohlke, U., Pullen, L., McDevitt, C.A., Porcelli, I., Palmer, T., Sabil, H.R. and Berks, B.C. (2005) The TatA component of the twin-arginine protein transport system forms channel complexes of variable diameter. Proc. Natl. Acad. Sci. 102:10482-10486 [pdf]

McDevitt, C.A., Hicks, M.G., Palmer, T., and Berks, B.C. (2005) Biochemical characterisation of null phenotype mutant Tat receptor complexes. Biochemical Biophysical Research Communications 329:693-8

McDevitt, C. A., Hanson, G. R., Noble, C., Cheesman, M. R., and McEwan, A. G. (2002) Characterisation of the redox centres from Dimethylsulfide Dehydrogenase of Rhodovulum sulfidophilum. Biochemistry 41:15234-44

McEwan, A.G., Ridge, J.P., McDevitt, C.A., and Hugenholtz, P. (2002) The DMSO reductase family of microbial molybdenum enzymes; molecular properties and role in the dissimilatory reduction of toxic elements. Geomicrobiology Journal 19:3-21

McDevitt, C.A., Hugenholtz, P., Hanson, G.R., and McEwan, A.G. (2002) Molecular analysis of Dimethylsulfide Dehydrogenase from Rhodovulum sulfidophilum; its place in the DMSO reductase family of microbial molybdopterin-containing enzymes. Molecular Microbiology 44:1575-87