Refereed Journal Articles

2017

Martin, J.M., Edmonds, K.A., Bruce, K.E., Campanello, G.C., Eijkelkamp, B.A., Brazel, E.B., McDevitt, C.A., Winkler, M.E., and Giedroc, D.P. (2017) The zinc efflux activator SczA protects Streptococcus pneumoniae 1 serotype 2 D39 from intracellular zinc toxicity Molecular Microbiology

Hassan, K.A., Pederick, V.G., Elbourne, L.D.H., Paulsen, I.T., Paton, J.C., McDevitt, C.A.# and Eijkelkamp B.A.# (2017) Zinc stress induces copper depletion in Acinetobacter baumannii. BMC Microbiology. (#co-corresponding authors)

Trappetti, C., McAllister, L.J., Chen, A., Wang, H., Paton, A.W., Oggioni, M.R., McDevitt, C.A., and Paton, J.C. (2017) Autoinducer 2 signaling via the phosphotransferase FruA drives galactose utilization by Streptococcus pneumoniae, resulting in hypervirulence. mBio. 8: e02269-16

2016

Heng, S., McDevitt, C.A., Kostecki, R., Morey, J.R., Eijkelkamp, B.A., Monro, T., Abell, A.D. (2016) Microstructured optical fiber-based biosensors: Reversible and nanoliter-scale measurement of zinc ions. ACS Applied Materials and Interfaces. 8:12727-32

2015

Luo, Z., Morey, J.R., McDevitt, C.A., Kobe B. Heterogeneous nucleation is required for crystallization of the ZnuA domain of pneumococcal AdcA. (2015) Acta Crystallogr. F Struct. Biol. Commun. 71:1459-1464

Eijkelkamp, B.A., Pederick, V.G., Plumptre, C.D., Harvey, R.M., Hughes, C.E., Paton, J.C., McDevitt, C.A. The first histidine triad motif of PhtD is critical for zinc homeostasis in Streptococcus pneumoniae. (2015) Infection and Immunity. doi: 10.1128/IAI.01082-15

Deplazes, E.*, Begg, S.L.*, van Wonderen, J.H., Cambpell, R., Kobe, B. Paton, J.C., MacMillan F., McDevitt, C.A.# and O'Mara M.L.# (2015) Characterising the conformational dynamics of metal-free PsaA using molecular dynamics simulations and electron paramagnetic resonance spectroscopy. Biophysical Chemistry. 207:51-60 [pdf] [*equal first author; #co-corresponding authors]

Pederick, V.G., Eijkelkamp, B.A., Begg, S.L., Ween, M.P., McAllister, L.J., Paton, J.C., and McDevitt, C.A. (2015) ZnuA and zinc homeostasis in Pseudomonas aeruginosa. Scientific Reports. 5:13139 [pdf]

Begg, S.L., Eijkelkamp, B.A., Luo, Z., Couñago, R.M., Morey, J.R., Maher, M.J., Ong C.Y., McEwan, A.G., Kobe, B., O'Mara M.L., Paton, J.C., and McDevitt, C.A. (2015) Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae. Nature Communications. 6:6418 [pdf]

Bajaj, M., Mamidyala, S.K., Zuegg, J., Begg, S.L., Ween, M.P., Luo, Z., Huang, J.X., McEwan, A.G., Kobe, B., Paton, J.C., McDevitt, C.A., and Cooper M.A. (2015) Discovery of novel Pneumococcal surface antigen A (PsaA) inhibitors using a fragment-based drug design approach. ACS Chemical Biology 10:1511-20 [pdf]

2014

Pederick, V.G., Eijkelkamp, B.A., Ween, M.P., Begg, S.L., Paton, J.C. and McDevitt, C.A. (2014) The acquisition and role of molybdate in Pseudomonas aeruginosa. Applied and Environmental Microbiology. 80:6843-6852 [pdf]

Plumptre, C.D., Hughes, C.E., Harvey, R.M., Eijkelkamp, B.A., McDevitt, C.A. and Paton, J.C. (2014) Overlapping functionality of the Pht proteins in zinc homeostasis of Streptococcus pneumoniae. Infection and Immunity. 82:4315-4324 [pdf]

van Wonderen J.H., McMahon R.M., O'Mara M.L., McDevitt C.A., Thomson A.J., Kerr I.D., MacMillan F., and Callaghan R. (2014) The central cavity of ABCB1 undergoes alternating access during ATP hydrolysis. FEBS Journal. 281:2190-201 [pdf]

Eijkelkamp, B.A., Morey, J.R., Ween, M.P., Ong, C.Y., McEwan, A.G., Paton, J.C., and McDevitt, C.A. (2014) Extracellular zinc competitively inhibits manganese uptake and compromises oxidative stress management in Streptococcus pneumoniaePLoS ONE. 9:e89427 [pdf]

Plumptre, C.D.*, Eijkelkamp, B.A.*, Morey, J.R., Behr, F., Couñago, R.M., Ogunniyi, A.D., Kobe B., O'Mara, M.L., Paton, J.C., and McDevitt, C.A. (2014) AdcA and AdcAII employ distinct zinc acquisition mechanisms and contribute additively to zinc homeostasis in Streptococcus pneumoniae. Molecular Microbiology. 91:834-51 [pdf] [*equal first author]

Couñago, R.M.*, Ween, M.P.*, Begg S.L., Bajaj, M., Zuegg, J., O'Mara, M.L., Cooper, M.A., McEwan, A.G., Paton, J.C., Kobe, B., and McDevitt, C.A. (2014) Imperfect coordination chemistry facilitates metal ion release in the Psa permease. Nature Chemical Biology. 10:35-41. [pdf] [*equal first author]
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Pollock, N.L., McDevitt, C.A., Collins, R.F., Niesten, P.H.M., Prince, S., Kerr, I.D., Ford, R.C., and Callaghan, R. (2014) Improving the stability and function of purified ABCB1 and ABCA4: The influence of membrane lipids. Biochim Biophys Acta. 1838:134-47. [pdf]

2013

Heng S., McDevitt C.A., Stubing D.B., Whittall J.J., Thompson J.G., Engler T.K., Abell A.D. and Monro T.M. (2013) Microstructured optical fibers and live cells: a water-soluble, photochromic zinc sensor. Biomacromolecules. 14:3376-9. [pdf]

2011

McDevitt, C.A., Ogunniyi, A.D., Valkov, E., Lawrence, M.C., Kobe, B., McEwan, A.G., and Paton, J.C. (2011) A molecular mechanism for bacterial susceptibility to zinc. PLoS Pathogens 7:e1002357 [pdf]

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2010 and earlier

Ogunniyi, A.D., Mahdi, L.K., Jennings, M.P., McEwan, A.G., McDevitt C.A., Van der Hoek, M.B., Bagley, C.J., Hoffman, P., Gould, K.A., and Paton, J.C. (2010) Central role of manganese in regulation of stress responses, physiology and metabolism in Streptococcus pneumoniae. Journal of Bacteriology 192:4489-97. [pdf]

McDevitt, C.A., Collins, R.F., Kerr, I.D., and Callaghan, R. (2009) Purification and structural analyses of ABCG2. Advanced Drug Delivery Reviews 61:57-65 [pdf]

McDevitt, C.A., Crowley, E.H., Hobbs, G., Starr, K., Kerr, I.D., and Callaghan, R. (2008) Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2? FEBS Journal 275:4354-62 [pdf]

McDevitt, C.A., Shintre, C.A., Grossmann, G.J., Pollock, N.L., Prince, S.M., Callaghan, R., Ford, R.C. (2008) Structural insights into P-glycoprotein (ABCB1) by small angle X-ray scattering and electron crystallography. FEBS Letters 582:2950-6 [pdf]

McDevitt, C.A., Sargent, F., Palmer, T., and Berks, B. C. (2006) Subunit composition and in vivo substrate-binding characteristics of Escherichia coli Tat protein complexes expressed at native levels. FEBS Journal 273:5656-68 [pdf]

McDevitt, C.A., Collins R.F., Conway M., Modok S., Storm J., Kerr I.D., Ford R.C. and Callaghan R., (2006) Purification and 3-D structural analysis of oligomeric human multidrug transporter ABCG2. Structure 14:1623-32 [pdf]

Gohlke, U., Pullen, L., McDevitt, C.A., Porcelli, I., Palmer, T., Sabil, H.R. and Berks, B.C. (2005) The TatA component of the twin-arginine protein transport system forms channel complexes of variable diameter. Proc. Natl. Acad. Sci. 102:10482-10486 [pdf]

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McDevitt, C.A., Hicks, M.G., Palmer, T., and Berks, B.C. (2005) Biochemical characterisation of null phenotype mutant Tat receptor complexes. Biochemical Biophysical Research Communications 329:693-8

McDevitt, C. A., Hanson, G. R., Noble, C., Cheesman, M. R., and McEwan, A. G. (2002) Characterisation of the redox centres from Dimethylsulfide Dehydrogenase of Rhodovulum sulfidophilum. Biochemistry 41:15234-44

McEwan, A.G., Ridge, J.P., McDevitt, C.A., and Hugenholtz, P. (2002) The DMSO reductase family of microbial molybdenum enzymes; molecular properties and role in the dissimilatory reduction of toxic elements. Geomicrobiology Journal 19:3-21

McDevitt, C.A., Hugenholtz, P., Hanson, G.R., and McEwan, A.G. (2002) Molecular analysis of Dimethylsulfide Dehydrogenase from Rhodovulum sulfidophilum; its place in the DMSO reductase family of microbial molybdopterin-containing enzymes. Molecular Microbiology 44:1575-87